Long-term analysis of antibodies elicited by SPUTNIK V: A prospective cohort study in Tucuman, Argentina.

ABSTRACT:

Background

Gam-COVID-Vac (SPUTNIK V) has been granted emergency use authorization in 70 nations and has been administered to millions worldwide. However, there are very few peer-reviewed studies describing its effects. Independent reports regarding safety and effectiveness could accelerate the final approval by the WHO. We aimed to study the long-term humoral immune response in naïve and previously infected volunteers who received SPUTNIK V.

Methods

Humoral immune responses, assayed by anti-SARS-CoV-2-spike-RBD IgG ELISA and neutralization assays, were measured in 602 healthcare workers at 0, 14, 28, 60 and 180 days after receiving SPUTNIK V between December 2020 and July 2021 in Tucumán, Argentina.

Findings

Seroconversion was detected in 97% of individuals after 28 d

SUBMITTER: Chahla RE 

PROVIDER: S-EPMC8604626 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature