Mutations of SARS-CoV-2 spike protein: Implications on immune evasion and vaccine-induced immunity.

ABSTRACT: Responsible for more than 4.9 million deaths so far, COVID-19, caused by SARS-CoV-2, is instigating devastating effects on the global health care system whose impacts could be longer for the years to come. Acquiring a comprehensive knowledge of host-virus interaction is critical for designing effective vaccines and/or drugs. Understanding the evolution of the virus and the impact of genetic variability on host immune evasion and vaccine efficacy is helpful to design novel strategies to minimize the effects of the emerging variants of concern (VOC). Most vaccines under development and/or in current use target the spike protein owning to its unique function of host receptor binding, relatively conserved nature, potent immunogenicity in inducing neutralizing antibodies, and being a good targe

SUBMITTER: Mengist HM 

PROVIDER: S-EPMC8604694 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature