A novel transcriptional risk score for risk prediction of complex human diseases.

ABSTRACT: Recently polygenetic risk score (PRS) has been successfully used in the risk prediction of complex human diseases. Many studies incorporated internal information, such as effect size distribution, or external information, such as linkage disequilibrium, functional annotation, and pleiotropy among multiple diseases, to optimize the performance of PRS. To leverage on multiomics datasets, we developed a novel flexible transcriptional risk score (TRS), in which messenger RNA expression levels were imputed and weighted for risk prediction. In simulation studies, we demonstrated that single-tissue TRS has greater prediction power than LDpred, especially when there is a large effect of gene expression on the phenotype. Multitissue TRS improves prediction accuracy when there are multiple tissues w

SUBMITTER: Shan N 

PROVIDER: S-EPMC8604733 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature