Macrophage polarization state affects lipid composition and the channeling of exogenous fatty acids into endogenous lipid pools.

ABSTRACT: Adipose-tissue-resident macrophages (ATMs) maintain metabolic homeostasis but also contribute to obesity-induced adipose tissue inflammation and metabolic dysfunction. Central to these contrasting effects of ATMs on metabolic homeostasis is the interaction of macrophages with fatty acids. Fatty acid levels are increased within adipose tissue in various pathological and physiological conditions, but appear to initiate inflammatory responses only upon interaction with particular macrophage subsets within obese adipose tissue. The molecular basis underlying these divergent outcomes is likely due to phenotypic differences between ATM subsets, although how macrophage polarization state influences the metabolism of exogenous fatty acids is relatively unknown. Herein, using stable isotope-labeled

SUBMITTER: Morgan PK 

PROVIDER: S-EPMC8604758 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature