Modeling of Glioma Growth With Mass Effect by Longitudinal Magnetic Resonance Imaging.

ABSTRACT: It is well-known that expanding glioblastomas typically induce significant deformations of the surrounding parenchyma (i.e., the so-called "mass effect"). In this study, we evaluate the performance of three mathematical models of tumor growth: 1) a reaction-diffusion-advection model which accounts for mass effect (RDAM), 2) a reaction-diffusion model with mass effect that is consistent only in the case of small deformations (RDM), and 3) a reaction-diffusion model that does not include the mass effect (RD). The models were calibrated with magnetic resonance imaging (MRI) data obtained during tumor development in a murine model of glioma (n = 9). We obtained T₂-weighted and contrast-enhanced T₁-weighted MRI at 6 time points over 10 days to determine the spatiotemporal

SUBMITTER: Tunc B 

PROVIDER: S-EPMC8604780 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature