OMA1 High-Throughput Screen Reveals Protease Activation by Kinase Inhibitors.

ABSTRACT: Mitochondrial proteases are interesting but challenging drug targets for multifactorial diseases, such as neurodegeneration and cancer. The mitochondrial inner membrane protease OMA1 is a bona fide drug target for heart failure supported by data from human linkage analysis and animal disease models, but presumably relevant for more indications. OMA1 acts at the intersection of energy metabolism and stress signaling. The protease cleaves the structural protein OPA1, which organizes the cristae, as well as the signaling peptide DELE1, which can stimulate the integrated stress response. OMA1 shows little activity under physiological conditions but hydrolyzes OPA1 in mitochondria destined for mitophagy and during apoptosis. Little is known about OMA1, its structure has not been solved, let alo

SUBMITTER: Alavi MV 

PROVIDER: S-EPMC8604787 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature