Bile acids contribute to the development of non-alcoholic steatohepatitis in mice.

ABSTRACT:

Background & aims

Through FXR and TGR5 signaling, bile acids (BAs) modulate lipid and glucose metabolism, inflammation and fibrosis. Hence, BAs returning to the liver after enteric secretion, modification and reabsorption may contribute to the pathogenesis of non-alcoholic steatohepatitis (NASH). Herein, we characterized the enterohepatic profile and signaling of BAs in preclinical models of NASH, and explored the consequences of experimental manipulation of BA composition.

Methods

We used high-fat diet (HFD)-fed foz/foz and high-fructose western diet-fed C57BL/6J mice, and compared them to their respective controls. Mice received a diet supplemented with deoxycholic acid (DCA) to modulate BA composition.

Results

Compared to controls, mice with NASH had lower c

SUBMITTER: Gillard J 

PROVIDER: S-EPMC8604813 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature