Tumor BRCA testing in ovarian cancer and EQA scheme: our experience of a critical evaluation.

ABSTRACT: Next generation sequencing (NGS) is a widespread molecular biology method integrated into clinical practice to detect genetic variants, for diagnostic and prognostic purposes. The scheduled external quality assessments (EQA) is integral part of clinical molecular laboratory quality assurance. The EQA provides an efficient system to compare analytic test performances among different laboratories, which is essential to evaluate consistency of molecular test. EQA failures demands targeted corrective action plans. In this context, the complexity of the NGS techniques requires careful and continuous quality control procedures. We report a tumor BRCA1/2 (tBRCA) testing benchmark discrepancy provided by the European Molecular Genetics Quality Network in our laboratory during a round of EQA for so

SUBMITTER: De Paolis E 

PROVIDER: S-EPMC8604882 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature