Identification S100A9 as a potential biomarker in neuroblastoma.

ABSTRACT:

Background

More than half of Neuroblastoma (NB) patients presented with distant metastases and the relapse of metastatic patients was up to 90%. It is urgent to explore a biomarker that could facilitate the prediction of metastasis in NB patients.

Methods and results

In the present study, we systematically analyzed Gene Expression Omnibus datasets and focused on identifying the critical molecular networks and novel key hub genes implicated in NB metastasis. In total, 176 up-regulated and 19 down-regulated differentially expressed genes (DEGs) were identified. Based on these DEGs, a PPI network composed of 150 nodes and 452 interactions was established. Through PPI network identification combined with qRT-PCR, ELISA and IHC, S100A9 was screened as an outstanding gene. Further

SUBMITTER: Chen X 

PROVIDER: S-EPMC8604885 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature