A national cohort study (2000-2018) of long-term air pollution exposure and incident dementia in older adults in the United States.

ABSTRACT: Air pollution may increase risk of Alzheimer's disease and related dementias (ADRD) in the U.S., but the extent of this relationship is unclear. Here, we constructed two national U.S. population-based cohorts of those aged ≥65 from the Medicare Chronic Conditions Warehouse (2000-2018), combined with high-resolution air pollution datasets, to investigate the association of long-term exposure to ambient fine particulate matter (PM_2.5), nitrogen dioxide (NO₂), and ozone (O₃) with dementia and AD incidence, respectively. We identified ~2.0 million incident dementia cases (N = 12,233,371; dementia cohort) and ~0.8 million incident AD cases (N = 12,456,447; AD cohort). Per interquartile range (IQR) increase in the 5-year average PM_2.5 (3.2 µg/m^3</

SUBMITTER: Shi L 

PROVIDER: S-EPMC8604909 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature