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Sound level context modulates neural activity in the human brainstem.

ABSTRACT: Optimal perception requires adaptation to sounds in the environment. Adaptation involves representing the acoustic stimulation history in neural response patterns, for example, by altering response magnitude or latency as sound-level context changes. Neurons in the auditory brainstem of rodents are sensitive to acoustic stimulation history and sound-level context (often referred to as sensitivity to stimulus statistics), but the degree to which the human brainstem exhibits such neural adaptation is unclear. In six electroencephalography experiments with over 125 participants, we demonstrate that the response latency of the human brainstem is sensitive to the history of acoustic stimulation over a few tens of milliseconds. We further show that human brainstem responses adapt to sound-level context in, at least, the last 44 ms, but that neural sensitivity to sound-level context decreases when the time window over which acoustic stimuli need to be integrated becomes wider. Our study thus provides evidence of adaptation to sound-level context in the human brainstem and of the timescale over which sound-level information affects neural responses to sound. The research delivers an important link to studies on neural adaptation in non-human animals.

SUBMITTER: Herrmann B

PROVIDER: S-EPMC8605015 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Sound level context modulates neural activity in the human brainstem.

Herrmann Björn B Yasmin Sonia S Araz Kurdo K Purcell David W DW Johnsrude Ingrid S IS

Scientific reports 20211119 1

Optimal perception requires adaptation to sounds in the environment. Adaptation involves representing the acoustic stimulation history in neural response patterns, for example, by altering response magnitude or latency as sound-level context changes. Neurons in the auditory brainstem of rodents are sensitive to acoustic stimulation history and sound-level context (often referred to as sensitivity to stimulus statistics), but the degree to which the human brainstem exhibits such neural adaptation ...[more]

PMID: 34799632

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Project description:Conceptors are a recent development in the field of reservoir computing; they can be used to influence the dynamics of recurrent neural networks (RNNs), enabling generation of arbitrary patterns based on training data. Conceptors allow interpolation and extrapolation between patterns, and also provide a system of boolean logic for combining patterns together. Generation and manipulation of arbitrary patterns using conceptors has significant potential as a sound synthesis method for applications in computer music but has yet to be explored. Conceptors are untested with the generation of multi-timbre audio patterns, and little testing has been done on scalability to longer patterns required for audio. A novel method of sound synthesis based on conceptors is introduced. Conceptular Synthesis is based on granular synthesis; sets of conceptors are trained to recall varying patterns from a single RNN, then a runtime mechanism switches between them, generating short patterns which are recombined into a longer sound. The quality of sound resynthesis using this technique is experimentally evaluated. Conceptor models are shown to resynthesise audio with a comparable quality to a close equivalent technique using echo state networks with stored patterns and output feedback. Conceptor models are also shown to excel in their malleability and potential for creative sound manipulation, in comparison to echo state network models which tend to fail when the same manipulations are applied. Examples are given demonstrating creative sonic possibilities, by exploiting conceptor pattern morphing, boolean conceptor logic and manipulation of RNN dynamics. Limitations of conceptor models are revealed with regards to reproduction quality, and pragmatic limitations are also shown, where rises in computation and memory requirements preclude the use of these models for training with longer sound samples. The techniques presented here represent an initial exploration of the sound synthesis potential of conceptors, demonstrating possible creative applications in sound design; future possibilities and research questions are outlined.

Dataset Information

Sound level context modulates neural activity in the human brainstem.

Publications

Sound level context modulates neural activity in the human brainstem.

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