The impact of weight loss on physical function and symptoms in overweight or obese breast cancer survivors: results from POWER-remote.

ABSTRACT:

Purpose

In pre-planned observational analysis of the POWER-remote trial, we examined the impact of weight loss on patient-reported outcomes (PROs). We hypothesized a priori that survivors with ≥ 5% weight loss would have improved physical function (PF) at 6 months vs. those who did not.

Methods

Patients with stage 0-III breast cancer who completed local therapy and chemotherapy with BMI ≥ 25 kg/m² were randomized to POWER-remote (telephone coaching; diet/activity tracking) or self-directed weight loss (booklet). Participants completed PROs at baseline, 6, and 12 months: PROMIS PF, pain, fatigue, anxiety, depression, sleep; FACT-endocrine symptoms; MOS-sexual function. Changes in PROs among those with ≥ 5% weight loss vs. those with < 5% were tested with multivaria

SUBMITTER: Sheng JY 

PROVIDER: S-EPMC8605026 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature