N-6 methylation-related lncRNA is potential signature in lung adenocarcinoma and influences tumor microenvironment.

ABSTRACT:

Background

N-6 methylation (m6A) pushes forward an immense influence on the occurrence and development of lung adenocarcinoma (LUAD). However, the methylation on non-coding RNA in LUAD, especially long non-coding RNA (lncRNA), has not been received sufficient attention.

Methods

Spearman correlation analysis was used to screen lncRNA correlated with m6A regulators expression from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) repositories, respectively. Then, the least absolute shrinkage and selection operator (LASSO) was applied to build a risk signature consisting m6A-related lncRNA. Univariate and multivariate independent prognostic analysis were applied to evaluate the performance of signature in predicting patients' survival. Next, we applied Gene Ontol

SUBMITTER: Zheng J 

PROVIDER: S-EPMC8605119 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature