The role of BDNF exon I region methylation in the treatment of depression with sertraline and its clinical diagnostic value.

ABSTRACT:

Background

Brain-derived neurotrophic factor (BDNF) is considered to be one of the best candidate genes for depression. However, whether sertraline treatment affects the methylation level of this gene remains unknown.

Methods

Fifty-three patients with depression and 51 healthy controls were included in the study. The methylation level of BDNF exon I was determined in blood samples from these subjects. The Hamilton Depression Scale was used to evaluate the depression status of patients. Single nucleotide polymorphism detection was used for genotyping, and a receiver operating characteristic (ROC) curve was used to evaluate the predictive value of the methylation level of this locus in patients with depression.

Results

There was a significant difference in the methylati

SUBMITTER: Xing Y 

PROVIDER: S-EPMC8605126 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature