Gene polymorphisms of insulin secretion signaling pathway associated with clopidogrel resistance in Han Chinese population.

ABSTRACT:

Background

Due to the loss of responsiveness to insulin, diabetes mellitus (DM) patients develop increased platelet reactivity and reduced response to antiplatelet agents. Nevertheless, the relationship between the single-nucleotide polymorphisms (SNP) of the signal pathway gene of insulin secretion and the effect of clopidogrel is elusive.

Methods

Blood samples were collected from patients administered with dual-antiplatelet therapy (clopidogrel, 75 mg, once daily and aspirin, 100 mg, once daily) after 5 days and completed test within 4 h. The VerifyNow P2Y12 assay was used to measure the platelet functions, and the results were expressed as a P2Y12 reaction unit (PRU). Notably, the selected SNPs were analyzed to demonstrate the functionality of genetic variants.

Results

SUBMITTER: Zhong J 

PROVIDER: S-EPMC8605143 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature