Performance of SPINK1 and SPINK1-based diagnostic model in detection of hepatocellular carcinoma.

ABSTRACT:

Objectives

To identify the SPINK1 or SPINK1-based model as a more reliable biomarker for the diagnosis of hepatocellular carcinoma (HCC).

Methods

Serum samples and related laboratory parameters were collected from 540 subjects (119 healthy donors, 113 patients with chronic hepatitis B, 122 patients with liver cirrhosis, and 186 patients with HCC). SPINK1 was determined by ELISA assay. Differences in each variable were compared by one-way ANOVA or Kruskal-Wallis test. ROC (receiver operating characteristic) curve analysis was conducted to compare the diagnostic efficiency of alpha-fetoprotein (AFP), SPINK1, and a SPINK1-based combine model constructed by binary Logistic regression.

Results

In detecting HCC using the other three groups as control, ROC curve analysis rev

SUBMITTER: Wang F 

PROVIDER: S-EPMC8605149 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature