Precision medicine for patients with gastro-oesophageal cancer: A subset analysis of the ProfiLER program.

ABSTRACT:

Background

Chemotherapy, anti-HER2 and PD-1 antibodies are standard treatments but only a minority of patients derive long-term benefit from these agents.

Methods

In this report we describe the mutational landscape and outcome of patients with gastroesophageal cancers enroled in the ProfiLER program.

Results

Adenocarcinoma (n = 86, 59%), signet-cell (n = 37, 25%) and squamous-cell (n = 21, 14%) were the dominant histology amongst 147 patients. Genomic analyses could be performed for 114 (78%) patients. The most common genomic alterations involved ERBB2 (15%), KRAS (12%), CCND1 (7%), FGFR1-3 (8%), EGFR (5%) and MET (3%), TP53 (51%) and CDKN2A/B (10%). ERBB2, MET and FGFR alterations were found exclusively in the adenocarcinoma and signet-cell subtypes, while CCND1 ampl

SUBMITTER: Cassier PA 

PROVIDER: S-EPMC8605190 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature