Association of chronic musculoskeletal pain with mortality among UK adults: A population-based cohort study with mediation analysis.

ABSTRACT:

Background

We aimed to quantify the association between chronic musculoskeletal pain and all-cause mortality, and to investigate the extent to which this association is mediated by physical activity, smoking status, alcohol consumption, and opioid use.

Methods

For this population-based cohort study, we used data from UK Biobank, UK between baseline visit (2006-2010) to 18th December 2020. We assessed the associations between chronic musculoskeletal pain and all-cause mortality using a Cox proportional hazards model. We performed causal mediation analyses to examine the proportion of the association between chronic musculoskeletal pain and all-cause mortality.

Findings

Of the 384,367 included participants, a total of 187,269 participants reported chronic musculoskeleta

SUBMITTER: Chen L 

PROVIDER: S-EPMC8605211 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature