Identification and localization of growth factor genes in the sea cucumber, Holothuria scabra.

ABSTRACT: The sea cucumber Holothuria scabra is both an economically important species in Asian countries and an emerging experimental model for research studies in regeneration and medicinal bioactives. Growth factors and their receptors are known to be key components that guide tissue repair and renewal, yet validation of their presence in H. scabra has not been established. We performed a targeted in silico search of H. scabra transcriptome data to elucidate conserved growth factor family and receptor genes. In total, 42 transcripts were identified, of which 9 were validated by gene cloning and sequencing. The H. scabra growth factor genes, such as bone morphogenetic protein 2A (BMP 2A), bone morphogenetic protein 5-like (BMP5-like)

SUBMITTER: Kornthong N 

PROVIDER: S-EPMC8605306 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature