DCNN-4mC: Densely connected neural network based N4-methylcytosine site prediction in multiple species.

ABSTRACT: DNA N4-methylcytosine (4mC) being a significant genetic modification holds a dominant role in controlling different biological functions, i.e., DNA replication, DNA repair, gene regulations and gene expression levels. The identification of 4mC sites is important to get insight information regarding different organics mechanisms. However, getting modification prediction from experimental methods is a challenging task due to high expenses and time-consuming techniques. Therefore, computational tools can be a great option for modification identification. Various computational tools are proposed in literature but their generalization and prediction performance require improvement. For this motive, we have proposed a neural network based tool named DCNN-4mC for identifying 4mC sites. The propos

SUBMITTER: Rehman MU 

PROVIDER: S-EPMC8605313 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature