Combined multimodal ctDNA analysis and radiological imaging for tumor surveillance in Non-small cell lung cancer.

ABSTRACT:

Background

Radiology is the current standard for monitoring treatment responses in lung cancer. Limited sensitivity, exposure to ionizing radiations and related sequelae constitute some of its major limitation. Non-invasive and highly sensitive methods for early detection of treatment failures and resistance-associated disease progression would have additional clinical utility.

Methods

We analyzed serially collected plasma and paired tumor samples from lung cancer patients (61 with stage IV, 48 with stages I-III disease) and 61 healthy samples by means of next-generation sequencing, radiological imaging and droplet digital polymerase chain reaction (ddPCR) mutation and methylation assays.

Results

A 62% variant concordance between tumor-reported and circulating-free DN

SUBMITTER: Metzenmacher M 

PROVIDER: S-EPMC8605355 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature