Atomically precise silver clusterzymes protect mice from radiation damages.

ABSTRACT:

Background

As we know, radiotherapy plays an irreplaceable role in the clinical management on solid tumors. However, due to the non-specific killing effects of ionizing radiation, normal tissues damages would be almost simultaneous inevitably. Therefore, ideal radioprotective agents with high efficiency and low toxicity are always desirable. In this work, atomically precise Ag₁₄ clusterzymes were developed, and their applications in radioprotection were studied in vitro and in vivo for the first time.

Methods

The ultra-small glutathione supported Ag₁₄ clusterzymes were synthesized by convenient sodium borohydride (NaBH₄) reduction of thiolate-Ag (I) complexes and then they were purified by desalting columns. The enzyme-like activity and antio

SUBMITTER: Guo J 

PROVIDER: S-EPMC8605545 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature