Remodeling of the tumor microenvironment via disrupting Blimp1⁺ effector Treg activity augments response to anti-PD-1 blockade.

ABSTRACT:

Background

Accumulation of Foxp3⁺ regulatory T (Treg) cells in the tumor often represents an important mechanism for cancer immune evasion and a critical barrier to anti-tumor immunity and immunotherapy. Many tumor-infiltrating Treg cells display an activated phenotype and express the transcription factor Blimp1. However, the specific impact of these Blimp1⁺ Treg cells and their follicular regulatory T (T_FR) cell subset on tumor and the underlying mechanisms of action are not yet well-explored.

Methods

Various transplantable tumor models were established in immunocompetent wild-type mice and mice with a Foxp3-specific ablation of Blimp1. Tumor specimens from patients with metastatic melanoma and TCGA datasets were analyzed to support the pote

SUBMITTER: Dixon ML 

PROVIDER: S-EPMC8605582 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature