Genome-wide identification and characterization of circular RNA m⁶A modification in pancreatic cancer.

ABSTRACT:

Background

N⁶-methyladenosine (m⁶A) is the most abundant modification of RNA in eukaryotic cells and play critical roles in cancer. While most related studies focus on m⁶A modifications in linear RNA, transcriptome-wide profiling and exploration of m⁶A modification in circular RNAs in cancer is still lacking.

Methods

For the detection of m⁶A modification in circRNAs, we developed a new bioinformatics tools called Circm6A and applied it to the m⁶A-seq data of 77 tissue samples from 58 individuals with pancreatic ductal adenocarcinoma (PDAC).

Results

Circm6A performs better than the existing circRNA identification tools, which achieved highest F1 score among these tools in the detection of circRNAs with m

SUBMITTER: Ye Y 

PROVIDER: S-EPMC8605608 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature