Mathematical modelling of SigE regulatory network reveals new insights into bistability of mycobacterial stress response.

ABSTRACT:

Background

The ability to rapidly adapt to adverse environmental conditions represents the key of success of many pathogens and, in particular, of Mycobacterium tuberculosis. Upon exposition to heat shock, antibiotics or other sources of stress, appropriate responses in terms of genes transcription and proteins activity are activated leading part of a genetically identical bacterial population to express a different phenotype, namely to develop persistence. When the stress response network is mathematically described by an ordinary differential equations model, development of persistence in the bacterial population is associated with bistability of the model, since different emerging phenotypes are represented by different stable steady states.

Results

In this work, we devel

SUBMITTER: Zorzan I 

PROVIDER: S-EPMC8605609 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature