Influence of Cognitive Reserve on Cognitive Trajectories: Role of Brain Pathologies.

ABSTRACT:

Background and objectives

Evidence on the association of cognitive reserve (CR) with the cognitive trajectories is limited. We aimed to examine the influence of CR indicator on domain-specific cognitive trajectories taking brain pathologies into account.

Methods

Within the Rush Memory and Aging Project, 1,697 participants without dementia (mean age 79.6 years) were followed up to 21 years. CR indicator encompassing education, early-life, mid-life, and late-life cognitive activities and late-life social activity was ascertained at baseline and categorized as tertiles (lowest, middle, and highest). Global cognition, episodic memory, semantic memory, working memory, visuospatial ability, and perceptual speed were assessed annually with 19 tests, from which composite scores were

SUBMITTER: Li X 

PROVIDER: S-EPMC8605617 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature