In Vitro and In Vivo Investigation of S1PR1 Expression in the Central Nervous System Using [³H]CS1P1 and [¹¹C]CS1P1.

ABSTRACT: Sphingosine-1-phosphate receptor 1 (S1PR1) is ubiquitously expressed among all tissues and plays key roles in many physiological and cellular processes. In the central nervous system (CNS), S1PR1 is expressed in different types of cells including neurons, astrocytes, and oligodendrocyte precursor cells. S1PR1 has been recognized as a novel therapeutic target in multiple sclerosis and other diseases. We previously reported a promising S1PR1-specific radioligand, [¹¹C]CS1P1 (previously named [¹¹C]TZ3321), which is under clinical investigation for human use. In the current study, we performed a detailed characterization of [³H]CS1P1 for its binding specificity to S1PR1 in CNS using autoradiography and immunohistochemistry in human and rat CNS tissues. Our data

SUBMITTER: Jiang H 

PROVIDER: S-EPMC8605766 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature