A Genome-Wide Association Study Identifies Novel Risk Loci for Sarcopenia in a Taiwanese Population.

ABSTRACT:

Purpose

A genome-wide association study (GWAS) of sarcopenia unraveled the importance of genetic contribution to decline in muscle. The current study investigated sarcopenia-related single nucleotide polymorphisms (SNPs) in Asian older adults, and further constructed a genotype score that tests the combined effect of these SNPs on risk of sarcopenia.

Patients and methods

Ninety-six subjects aged 60 or above were recruited from the database of annual geriatric health examination at Tri-Service General Hospital during 2020. Eligible criteria included: 1) not having severe comorbidities; 2) agreed to join the Taiwan Precision Medicine Initiative project; and 3) having sufficient information of required sarcopenic measurements. Genotype-phenotype association analysis was perform

SUBMITTER: Wu SE 

PROVIDER: S-EPMC8605878 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature