Reinforcement learning links spontaneous cortical dopamine impulses to reward.

ABSTRACT: In their pioneering study on dopamine release, Romo and Schultz speculated "...that the amount of dopamine released by unmodulated spontaneous impulse activity exerts a tonic, permissive influence on neuronal processes more actively engaged in preparation of self-initiated movements...."¹ Motivated by the suggestion of "spontaneous impulses," as well as by the "ramp up" of dopaminergic neuronal activity that occurs when rodents navigate to a reward,^2-5 we asked two questions. First, are there spontaneous impulses of dopamine that are released in cortex? Using cell-based optical sensors of extrasynaptic dopamine, [DA]_ex,⁶ we found that spontaneous dopamine impulses in cortex of naive mice occur at a rate of ∼0.01 per second. Next, can mice be trai

SUBMITTER: Foo C 

PROVIDER: S-EPMC8605927 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature