Animal models of chemotherapy-induced cognitive decline in preclinical drug development.

ABSTRACT:

Rationale

Chemotherapy-induced cognitive impairment (CICI), chemobrain, and chemofog are the common terms for mental dysfunction in a cancer patient/survivor under the influence of chemotherapeutics. CICI is manifested as short/long term memory problems and delayed mental processing, which interferes with a person's day-to-day activities. Understanding CICI mechanisms help in developing therapeutic interventions that may alleviate the disease condition. Animal models facilitate critical evaluation to elucidate the underlying mechanisms and form an integral part of verifying different treatment hypotheses and strategies.

Objectives

A methodical evaluation of scientific literature is required to understand cognitive changes associated with the use of chemotherapeutic agents in

SUBMITTER: John J 

PROVIDER: S-EPMC8605973 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature