Individual differences in social play behaviour predict alcohol intake and control over alcohol seeking in rats.

ABSTRACT:

Rationale

Social play behaviour is a rewarding social activity displayed by young mammals, thought to be important for the development of brain and behaviour. Indeed, disruptions of social play behaviour in rodents have been associated with cognitive deficits and augmented sensitivity to self-administration of substances of abuse, including alcohol, later in life. However, the relation between social development and loss of control over substance use, a key characteristic of substance use disorders including alcohol use disorder (AUD), has not been investigated. Moreover, it remains unknown how inherent differences in playfulness relate to differences in the sensitivity to substance use and AUD.

Objective

The objective of this study is to determine how individual differences

SUBMITTER: Lesscher HMB 

PROVIDER: S-EPMC8605978 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature