Short-term exercise affects cardiac function ex vivo partially via changes in calcium channel levels, without influencing hypoxia sensitivity.

ABSTRACT: Exercise is known to improve cardiac recovery following coronary occlusion. However, whether short-term exercise can improve cardiac function and hypoxia tolerance ex vivo independent of reperfusion injury and the possible role of calcium channels in improved hypoxia tolerance remains unknown. Therefore, in the current study, heart function was measured ex vivo using the Langendorff method at different oxygen levels after a 4-week voluntary wheel-running regimen in trained and untrained male mice (C57Bl/6NCrl). The levels of cardiac Ca²⁺-channels: L-type Ca²⁺-channel (CACNA1C), ryanodine receptor (RyR-2), sarco(endo)plasmic reticulum Ca²⁺-ATPase (SERCA2), and sodium-calcium exchanger were measured using western blot. Trained mice displayed lower cardiac aft

SUBMITTER: Uurasmaa TM 

PROVIDER: S-EPMC8605979 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature