A role for reward valuation in the serotonergic modulation of impulsivity.

ABSTRACT:

Rationale

Impulsive behavior is a deleterious component of a number of mental health disorders but has few targeted pharmacotherapies. One contributing factor to the difficulty in understanding the neural substrates of disordered impulsivity is the diverse presentations of impulsive behavior. Defining the behavioral and cognitive processes which contribute to different subtypes of impulsivity is important for understanding the neural underpinnings of dysregulated impulsive behavior.

Methods

Using a mouse model for disordered impulsivity, our goal was to identify behavioral and cognitive processes that are associated with increased impulsivity. Specifically, we were interested in the facets of impulsivity modulated by serotonin signaling. We used mice lacking the serotonin 1B

SUBMITTER: Desrochers SS 

PROVIDER: S-EPMC8605981 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature