Pancreas cancer: Therapeutic trials in metastatic disease.
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ABSTRACT:
SUBMITTER: Smithy JW
PROVIDER: S-EPMC8606164 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Publications
Pancreas cancer: Therapeutic trials in metastatic disease.
Smithy James W JW O'Reilly Eileen M EM
Journal of surgical oncology 20210501 6
Metastatic pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer-related mortality in 2021. Cytotoxic therapies are the therapeutic mainstay for PDAC. The recent approval of olaparib as maintenance therapy for germline BRCA1/2-mutated PDAC and pembrolizumab for mismatch repair deficient PDAC represent molecularly targeted approaches for this disease. Investigational therapeutic strategies include targeting the stroma, metabolism, tumor microenvironment, and the immune system, and se ...[more]
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