Heritability and genome-wide association study of blood pressure in Chinese adult twins.

ABSTRACT:

Background

Blood pressure (BP) is an independent and important factor for chronic diseases such as cardiovascular diseases and diabetes.

Methods

We firstly conducted twin modeling analyses to explore the heritability of BP, including systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP) and mean arterial pressure (MAP), and then performed genome-wide association studies to explore the associated genomic loci, genes, and pathways.

Results

A total of 380 Chinese twin pairs were included. The AE model containing additive genetic parameter (A) and unique/non-shared environmental parameter (E) was the best fit model, with A accounting for 53.7%, 50.1%, 48.1%, and 53.3% for SBP, DBP, PP and MAP, respectively. No SNP was found to reach the genome

SUBMITTER: Chen J 

PROVIDER: S-EPMC8606211 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature