Associations of longitudinal plasma p-tau181 and NfL with tau-PET, Aβ-PET and cognition.

ABSTRACT:

Objective

To explore if changes over time of plasma phosphorylated tau (p-tau)181 and neurofilament light chain (NfL) predict future tau and amyloid β (Aβ) PET load and cognitive performance, we studied a subsample of the Alzheimer's disease (AD) neuroimaging cohort with longitudinal blood peptide assessments.

Methods

Eight hundred and sixty-five AD Neuroimaging Initiative participants were included. Using established AD cut-points for the cerebrospinal fluid concentrations of Aβ42, total-tau and p-tau181, subjects were classified according to the National Institute on Aging-Alzheimer's Association research framework, grouping markers into those of Aβ deposition (A), tau pathology (T) and neurodegeneration (N). Analysis of variance was used to compare the plasma biomarker da

SUBMITTER: Rauchmann BS 

PROVIDER: S-EPMC8606440 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature