Genome-wide association study identifies TNFSF15 associated with childhood asthma.

ABSTRACT:

Background

Genome-wide association studies (GWASs) of asthma have identified several risk alleles and loci, but most have been conducted in individuals with European-ancestry. Studies in Asians, especially children, are still lacking. We aimed to identify susceptibility loci by performing the first GWAS of asthma in Korean children with persistent asthma.

Methods

We used a discovery set of 741 children with persistent asthma as cases and 589 healthy children and 551 healthy adults as controls to perform a GWAS. We validated our GWAS findings using UK Biobank data. We then used the Genotype-Tissue Expression database to identify expression quantitative trait loci of candidate variants. Finally, we quantified proteins of genes associated with asthma.

Results

Variants at

SUBMITTER: Kim KW 

PROVIDER: S-EPMC8606614 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature