Characterization of Alzheimer's Disease-Associated Excitatory Neurons via Single-Cell RNA Sequencing Analysis.

ABSTRACT: The detailed characteristics of neuronal cell populations in Alzheimer's disease (AD) using single-cell RNA sequencing have not been fully elucidated. To explore the characterization of neuronal cell populations in AD, this study utilized the publicly available single-nucleus RNA-sequencing datasets in the transgenic model of 5X familial Alzheimer's disease (5XFAD) and wild-type mice to reveal an AD-associated excitatory neuron population (C3:Ex.Neuron). The relative abundance of C3:Ex.Neuron increased at 1.5 months and peaked at 4.7 months in AD mice. Functional pathways analyses showed that the pathways positively related to neurodegenerative disease progression were downregulated in the C3:Ex.Neuron at 1.5 months in AD mice. Based on the differentially expressed genes among the C3:Ex.Ne

SUBMITTER: Shao F 

PROVIDER: S-EPMC8606650 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature