Autonomic Imbalance Increases the Risk for Non-alcoholic Fatty Liver Disease.

ABSTRACT:

Background

Although autonomic imbalance is associated with an increased risk for metabolic disease, its effects on nonalcoholic fatty liver disease (NAFLD) remains unclear. We aimed to evaluate whether autonomic dysfunction predicts the risk for nonalcoholic fatty liver disease (NAFLD).

Methods

A total of 33,899 participants without NAFLD who underwent health screening programs between 2011 and 2018 were enrolled. NAFLD was identified by ultrasonography. Autonomic activity was estimated using heart rate variability (HRV). Time domain [standard deviation of the normal-to-normal interval (SDNN) and root mean square difference (RMSSD)]; frequency domain [total power (TP), low frequency (LF), and high frequency (HF), and LF/HF ratio were analyzed.

Findings

A total 6,466 p

SUBMITTER: Jung I 

PROVIDER: S-EPMC8606663 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature