T-cell intrinsic Toll-like receptor signaling: implications for cancer immunotherapy and CAR T-cells.

ABSTRACT: Toll-like receptors (TLRs) are evolutionarily conserved molecules that specifically recognize common microbial patterns, and have a critical role in innate and adaptive immunity. Although TLRs are highly expressed by innate immune cells, particularly antigen-presenting cells, the very first report of a human TLR also described its expression and function within T-cells. Gene knock-out models and adoptive cell transfer studies have since confirmed that TLRs function as important costimulatory and regulatory molecules within T-cells themselves. By acting directly on T-cells, TLR agonists can enhance cytokine production by activated T-cells, increase T-cell sensitivity to T-cell receptor stimulation, promote long-lived T-cell memory, and reduce the suppressive activity of regulatory T-cells.

SUBMITTER: Nouri Y 

PROVIDER: S-EPMC8606765 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature