Broadly neutralizing monoclonal antibodies for HIV prevention.

ABSTRACT:

Introduction

The last 12 years have seen remarkable progress in the isolation and characterization of at least five different epitope classes of HIV-specific broadly neutralizing antibodies (bnAbs). Detailed analyses of these bnAb lineages, maturation pathways and epitopes have created new opportunities for vaccine development. In addition, interest exists in passive administration of monoclonal antibodies as a viable option for HIV prevention.

Discussion

Recently, two antibody-mediated prevention (AMP) trials of a passively administered monoclonal antibody targeting the HIV envelope CD4 binding site, called VRC01, provided proof-of-concept that monoclonal antibody infusion could offer protection against HIV acquisition. While the trials failed to show overall protection aga

SUBMITTER: Miner MD 

PROVIDER: S-EPMC8606861 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature