Structure-guided envelope trimer design in HIV-1 vaccine development: a narrative review.

ABSTRACT:

Introduction

The development of a human immunodeficiency virus 1 (HIV-1) vaccine remains a formidable challenge. An effective vaccine likely requires the induction of broadly neutralizing antibodies (bNAbs), which likely involves the use of native-like HIV-1 envelope (Env) trimers at some or all stages of vaccination. Development of such trimers has been very difficult, but much progress has been made in the past decade, starting with the BG505 SOSIP trimer, elucidation of its atomic structure and implementing subsequent design iterations. This progress facilitated understanding the weaknesses of the Env trimer, fuelled structure-guided HIV-1 vaccine design and assisted in the development of new vaccine designs. This review summarizes the relevant literature focusing on studies usi

SUBMITTER: Derking R 

PROVIDER: S-EPMC8606863 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature