Strategies for induction of HIV-1 envelope-reactive broadly neutralizing antibodies.

ABSTRACT:

Introduction

A primary focus of HIV-1 vaccine development is the activation of B cell receptors for naïve or precursor broadly neutralizing antibodies (bnAbs), followed by expansion and maturation of bnAb B cell lineage intermediates leading to highly affinity-matured bnAbs. HIV-1 envelope (Env) encodes epitopes for bnAbs of different specificities. Design of immunogens to induce bnAb precursors of different specificities and mature them into bnAb status is a goal for HIV-1 vaccine development. We review vaccine strategies for bnAb lineages development and highlight the immunological barriers that these strategies must overcome to generate bnAbs.

Methods

We provide perspectives based on published research articles and reviews.

Discussion

The recent Antibody Mediated P

SUBMITTER: Williams WB 

PROVIDER: S-EPMC8606870 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature