Current approaches to HIV vaccine development: a narrative review.

ABSTRACT:

Introduction

The development of an effective vaccine to protect against HIV is a longstanding global health need complicated by challenges inherent to HIV biology and to the execution of vaccine efficacy testing in the context of evolving biomedical prevention interventions. This review describes lessons learnt from previous efficacy trials, highlights unanswered questions, and surveys new approaches in vaccine development addressing these gaps.

Methods

We conducted a targeted peer-reviewed literature search of articles and conference abstracts from 1989 through 2021 for HIV vaccine studies and clinical trials. The US National Library of Medicine's Clinical Trials database was accessed to further identify clinical trials involving HIV vaccines. The content of the review was

SUBMITTER: Kim J 

PROVIDER: S-EPMC8606871 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature