C24:0 avoids cold exposure-induced oxidative stress and fatty acid β-oxidation damage.

ABSTRACT: Low temperatures can cause severe growth inhibition and mortality in fish. Previous studies about the cold resistance of fish mainly focused on the role of unsaturated fatty acids, rather than saturated fatty acids (SFAs). In this study, the role of very-long-chain SFA synthetized by fatty acyl elongase 1 gene (elovl1) in cold resistance was explored. Both an aggravated liver oxidative stress and a mitochondrial metabolism disorder were observed in elovl1a ^-/- and elovl1b ^-/- zebrafish with cold stress. In vitro studies confirmed that high levels of C20:0 and C22:0 obviously increased the hepatocyte oxidative stress and activated the extracellular signal-regulated kinases 1/2 (Erk1/2) pathway to further induce apoptosis and in

SUBMITTER: Sun S 

PROVIDER: S-EPMC8607208 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature