Breast cancer risk stratification for mammographic screening: A nation-wide screening cohort of 24,431 women in Singapore.

ABSTRACT:

Background

Breast cancer incidence is increasing in Asia. However, few women in Singapore attend routine mammography screening. We aim to identify women at high risk of breast cancer who will benefit most from regular screening using the Gail model and information from their first screen (recall status and mammographic density).

Methods

In 24,431 Asian women (50-69 years) who attended screening between 1994 and 1997, 117 developed breast cancer within 5 years of screening. Cox proportional hazard models were used to study the associations between risk classifiers (Gail model 5-year absolute risk, recall status, mammographic density), and breast cancer occurrence. The efficacy of risk stratification was evaluated by considering sensitivity, specificity, and the proportion of

SUBMITTER: Ho PJ 

PROVIDER: S-EPMC8607242 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature