Prognostic implication of PD-L1 polymorphisms in non-small cell lung cancer treated with radiotherapy.

ABSTRACT:

Background

To investigate the impact of programmed death-ligand 1 (PD-L1) polymorphisms on the prognosis of non-small cell lung cancer (NSCLC) patients treated with curative radiotherapy.

Methods

Four single nucleotide polymorphisms (SNPs) (rs822336G>C, rs822337T>A, rs822338C>T, and rs2297136A>G) in the PD-L1 gene were evaluated in 124 NSCLC patients. Clinical stage was I in 28, II in 17, and III in 79 patients. Fifty-seven patients received radiotherapy alone, including 28 patients who received stereotactic body radiotherapy. Sixty-seven patients received sequential or concurrent chemoradiotherapy. Risk factors for survival outcomes were analyzed with the log-rank test and multivariate Cox proportional hazards models.

Results

The rs822336GC+CC genotype was associated

SUBMITTER: Kang MK 

PROVIDER: S-EPMC8607250 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature