A construction and comprehensive analysis of ceRNA networks and infiltrating immune cells in papillary renal cell carcinoma.

ABSTRACT:

Background

As the second most common malignancy in adults, papillary renal cell carcinoma (PRCC) has shown an increasing trend in both incidence and mortality. Effective treatment for advanced metastatic PRCC is still lacking. In this study, we aimed to establish competitive endogenous RNA (ceRNA) networks related to PRCC tumorigenesis, and analyze the specific role of differentially expressed ceRNA components and infiltrating immune cells in tumorigenesis.

Methods

CeRNA networks were established to identify the key ceRNAs related to PRCC tumorigenesis based on the 318 samples from The Cancer Genome Atlas database (TCGA), including 285 PRCC and 33 normal control samples. The R package, "CIBERSORT," was used to evaluate the infiltration of 22 types of immune cells. Then we id

SUBMITTER: Fan Y 

PROVIDER: S-EPMC8607257 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature