The association between vincristine-induced peripheral neuropathy and health-related quality of life in children with cancer.

ABSTRACT:

Purpose

Vincristine (VCR) is a chemotherapeutic agent used in the treatment of pediatric oncology patients, but its main toxicity is VCR-induced peripheral neuropathy (VIPN). However, whether VIPN has an effect on health-related quality of life (HR-QoL) in children during treatment is unknown. Therefore, the aim of our study was to investigate the association between VIPN and HR-QoL in children starting treatment for cancer.

Methods

Measurements of VIPN were performed using two tools: Common Terminology Criteria for Adverse Events (CTCAE) and pediatric-modified Total Neuropathy Score (ped-mTNS). Assessment of HR-QoL was done with self- and proxy assessment of the Cancer and Generic module of the Pediatric Cancer Quality of Life Inventory™ (PedsQL).

Results

In total, N

SUBMITTER: van de Velde ME 

PROVIDER: S-EPMC8607258 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature