Association of radiation dose intensity with overall survival in patients with distant metastases.

ABSTRACT:

Background

Patients with metastatic cancer referred to radiation oncology have diverse prognoses and there is significant interest in personalizing treatment. We hypothesized that patients selected for higher biologically equivalent doses have improved overall survival.

Methods

The study population consists of 355 consecutive adult patients with distant metastases treated by a single radiation oncologist from 2014 to 2018. The validated NEAT model was used to prospectively stratify patients into four distinct cohorts. Radiation dose intensity was standardized using the equivalent dose in 2 Gy fractions (EQD2) model with an α/β of 10. Radiation dose intensity on survival was assessed via Cox regression models and propensity score match pairing with Kaplan-Meier analysis.

R

SUBMITTER: Kao J 

PROVIDER: S-EPMC8607262 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature